Thermal decomposition behavior of blocked diisocyanates derived from mixture of blocking agents macromol. Buy high quality chlorosulfonyl isocyanate 1189715 from carbosynth, your source for carbohydrates, nucleosides and fine chemicals. Full text of sulfonation and relatated reactions see other formats. Since then it has proven to be the most reactive isocyanate known. Its nbenzyl derivative 3 was selectively prepared by the reaction of 2benzylaminopyridine with either chlorosulfonyl isocyanate. Synthesis of carboxylic acids, esters and their derivatives. Sodium cyclamate manufacturer, sodium lactate supplier,exporter. When heated to decomposition it emits toxic fumes of nox. Chlorosulfonyl isocyanate reacts with hydrocarbon alkenes via stepwise dipolar pathway to give n chlorosulfonyl. It is used in medicine industry for synthesizing cefuroxime, cefoxitin, etc. Acts as a single source for synthetic methods of carboxylic acids, esters, acid halides, anhydrides, amides and imides covering general and newer methods of preparation from 19671987. Physical properties about chlorosulfonyl isocyanate are. Reaction of chlorosulfonyl isocyanate csi with fluorosubstituted alkenes. The extensively crossreferenced book enables readers to avoid explosion and loss of containment of chemicals.
Kinetic studies on the reaction of chlorosulfonyl isocyanate. When heated to decomposition it emits very toxic fumes of cl, f, and sox. Avanschem is a producer of a wide range of sweeteners, from dxylose, fructooligosaccharide fos, fructose to stevia. The chemistry of chlorosulfonyl isocyanate is an important book that should serve as a onestop ready reference for researchers interested in the study of csi. Chemicalbook cas database list chlorosulfonyl isocyanate. Panjiva uses over 30 international data sources to help you find qualified vendors of chlorosulfonyl.
General reactivity and applications of chlorosulfonyl. The reaction was carried out until disappearance of nco peak in the ftir spectrum. The tricyclic aziridine derivatives 4ac undergo csi extrusion reactions and subsequent oxidation to the corresponding pyrazines 5ac. It consists of two electronwithdrawing components, the chlorosulfonyl group so 2 cl and the isocyanate group nco. Section 1 chemical product and company identification. Chlorosulfonyl isocyanate sc255017 hazard alert code key. Stereoselective amination of chiral benzylic ethers using. Full text of handbook of reactive chemical hazards vol 2.
In the case of h 12 mdi, the reaction was performed in a thermostat. Because of its resulting electrophilicity, the use of csi in chemical synthesis requires relatively inert solvents such as chlorocarbons, acetonitrile, and ethers. It is synthetically versatile reagent and was used in the. If csi is partially decomposed by moisture, will it be able to be used as a. Evidence of a concerted pathway for reaction of csi with fluorosubstituted alkenes preprint. Reaction of chlorosulfonyl isocyanate with bridge bi and. Structure, properties, spectra, suppliers and links for. After a few minutes the solution becomes clear and, after about onehalf of the isocyanate has been added, the carboxylic acid amide nsulfonyl chloride begins to precipitate. Full text of handbook of reactive chemical hazards vol 2 bretherick 1999 see other formats. The synthesis of chlorosulfonyl isocyanate csi 1 by the reaction of sulfur trioxide with cyanogen chloride was reported by graf in 1956 1. Chlorosulfonyl isocyanate,1189715,price,manufacturer,supplier. Non or partial spin labeling indicates decomposition of isocyanate 1. Offers wide range of products which includes chlorosulfonyl isocyanate.
Structural identifications of 3ac and 4ac are based on ir, nmr and mass spectral data. Chlorosulfonyl isocyanate siping fine chemicals co. Organic syntheses utilizing the chemical properties of. It is relatively more reactive than alkyl sulfonyl isocyanates in olefin additions by as much as 1x10 2.
Burgess and martin dehydrating reagents freebooksummary. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Acetone is not recommended, as chlorosulfonyl isocyanate may react with it. Recently, a novel synthetic method for nallylcarbamate formation from various alkyl allyl ethers using chlorosulfonyl isocyanate csi was reported. The stereochemistry of the annulation product was employed to control the installation of the indolylmethyl side chain at c7 with complete stereoselectivity. Chlorosulfonyl isocyanate chemical information, properties, structures, articles, patents and more chemical data. Chlorosulfonyl isocyanate specific hazards none known.
Reaction of chlorosulfonyl isocyanate with bridge bi and tricyclic olefins emil j. A novel asymmetric synthesis of unsaturated aromatic 1,2amino alcohols. Chlorosulfonyl isocyanate is the chemical compound clso 2 nco, known as csi. Chlorosulfonyl isocyanate reacts violently with water. Chlorosulfonyl isocyanate 1189715 pricing, chemical properties, structure, cas number, molecular formula. There is an open access version for this licensed article that can be read free of charge and without license restrictions. Chlorosulfonyl isocyanate is the chemical compound clso2nco, known as csi.
Study of the stability of carbocations by chlorosulfonyl. Woods the ici polyurethanes book, wiley, newyork, 1990, search pubmed. Jan 18, 20 kinetic studies on the reaction of chlorosulfonyl isocyanate with monofluoroalkenes. At last,propyl isocyanate110781 safety, risk, hazard and msds, cas,cas number,use,cas no. Hazardous combustion products thermal decomposition or combustion products may include the following substances. Sigmaaldrich offers a number of chlorosulfonyl isocyanate products. Dlid englishcatalogue part 2 of 15 sanskrit documents.
For safety reasons, therefore, it is recommended that either air or dry ice mixtures be used for all cooling condensers and cooling baths. Stereoselective amination of chiral benzylic ethers using chlorosulfonyl isocyanate. General reactivity and applications of chlorosulfonyl isocyanate csi daniel tzvi cohen long literature presentation january 7, 2010 n c o s cl o o. Chlorosulfonyl manufacturers suppliers of chlorosulfonyl. Chlorosulfonyl isocyanate miller major reference works wiley. Chlorosulphonyl isocyanate registration dossier echa. Chlorosulfonyl isocyanate is used for the preparation of.
Sustainable routes to polyurethane precursors green chemistry. Advice for firefighters special protective equipment for firefighters. The compound 250 was reacted with chlorosulfonyl isocyanate followed by ethanol or ptoluenesulfonyl isocyanate to give, respectively, 251 in 33% yield and 252 in 59% yield equation 20. This compound is a versatile reagent in organic synthesis.
Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Regioselective and diastereoselective allylic amination using chlorosulfonyl isocyanate. In the case of chlorosulfonyl isocyanate, the reaction competed with an electrophilic substitution at the 2position, forming 253 in 31% yield. Chlorosulfonyl isocyanate was used in synthesis and biochemical characterization of new class of membraneassociated glycosyltransferase inhibitors. The content of the open access version may differ from that of the licensed version. These sugar substitutes are added in different products, from pharmaceutical products, confectionery, beverages to food items. The chemistry of chlorosulfonyl isocyanate hardcover october 28, 2002. Chlorosulfonyl isocyanate 1189715 carbosynth product. Pdf reaction of chlorosulfonyl isocyanate csi with. Kinetic studies on the reaction of chlorosulfonyl isocyanate with monofluoroalkenes. Figure 3 illustrates the treatment of csi with anhydrous methanol and dry benzene at temperatures ranging from 2530c, for approximately halfhour. Addition reactions of chlorosulfonyl isocyanate suresh chander suri. Brain targeted delivery of curcumin using p80 peg coated.
Glass stoppers of bottles used for storage of csi stick fast after a short time, even when covered with silicone grease, so that polyethylene bottles with screw caps are best for longer storage times a few weeks. It is also widely used in the synthetic of antibiotics, agricultural chemicals, polymers, etc. Chlorosulfonyl isocyanate price,buy chlorosulfonyl isocyanate. Thermal decomposition behavior of blocked diisocyanates. Brethericks handbook of reactive chemical hazards, eighth edition presents the latest updates on the unexpected, but predictable, loss of containment and explosion hazards from chemicals and their admixtures and actual accidents. Extreme high moderate low section 1 chemical product and company identification product name chlorosulfonyl isocyanate statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. The reaction proceeds via concerted mechanism rather than a. Chlorosulfonyl isocyanate 1189715 c2088 spectrum chemical. The decomposition of carbamates applying temperatures above 250 c in the. Cycloaddition of chlorosulfonyl isocyanate to 2hazirines. Csi can undergo two types of nucleophilic addition, namely to the carbonyl carbon and to the sulfur of the. It is easily prepared by the reaction of chlorosulfonyl isocyanate with. Brethericks handbook of reactive chemical hazards 8th.